Sr Principal Eng - Process Engineering

Position Summary We are searching for the best talent for a Sr Principal Eng – Process Engineering to join our team! This is an onsite/hybrid role. The role is available across multiple countries; please focus on the country(s) that align with your preferred location(s). Requisition Numbers: Belgium & Italy – R-Visualizzare il telefono su euspert.app, Puerto Rico – R-076777, Switzerland – R-076783. As the GET PE – Synthetics Drug Product Manufacturing Senior Principal Engineer, you will lead early design inputs and technical strategy for synthetic's drug product manufacturing processes within strategic capital projects, network studies, and technology platforms across IMSC. You will provide deep technical expertise in synthetic's controlled bioburden‑drug product manufacturing (OSD and innovative forms such as semi‑solid) and drug product intermediate through bioavailability enhanced technologies, while supporting solving and optimization activities at internal and external manufacturing sites. Joining our global engineering group, you will collaborate with high‑performing, multi‑functional teams across multiple sites and functions. This role offers a dynamic and inspiring work environment with significant opportunities to influence technology direction, standardization, and capability building across the network. Responsibilities and Impact You Will Have

Lead the intake, scoping, prioritization, and resolution of synthetics controlled bioburden‑drug product manufacturing related technical requests across global sites. Lead and influence early‑phase process design and domain expertise for oral solid dose (OSD) products, covering both batch and continuous manufacturing platforms; as well as new innovative drug product forms. Lead and influence early‑phase process design and domain expertise for bioavailability enhanced technologies, including amorphous solid dispersions (ASD) with a strong emphasis on spray drying, as well as other technologies such as Self‑Emulsifying Drug Delivery Systems (SEDDS) and other related innovative drug product intermediate formulation approaches. Ensure robust, fit‑for‑purpose process design while promoting standardization and platform approaches where they make valuable contributions. Provide expert input and alignment on key process, equipment, and technology selection decisions for drug product manufacturing. Actively collaborate with other functions such as R&D, MSAT, Quality, EHS, and Operations leads across synthetic drug product sites. Find opportunities for harmonization, shared solutions, and best‑practice exchange across the network. Foster a culture of collaboration to reduce duplication, accelerate implementation, and improve speed‑to‑market. Maintain strong connections with industry experts and external networks (e.g., ISPE) to bring innovative drug product manufacturing solutions into the organization. Ensure alignment with enterprise strategies, GMP requirements, and technology roadmaps. Collaborate with External Manufacturing teams to prioritize support and resolve issues for high‑impact programs and partners.

Qualifications Education

Minimum of a Master’s degree or equivalent experience in Engineering, Pharmaceutical Sciences, or a related technical field is required.

Experience and Skills

Minimum 10 years of relevant experience in synthetics controlled bioburden drug product manufacturing, with a strong focus on oral solid dose (OSD) processes and innovative technologies (e.g., semi‑solid) in drug product pharmaceutical manufacturing environments. Demonstrated expertise in bioavailability enhanced technologies, including ASD (amorphous solid dispersions) with deep knowledge of spray drying and SEDDS or similar innovative enabling formulation approaches. Proven experience with OSD controlled bioburden manufacturing, including batch and continuous manufacturing processes and associated equipment. Strong understanding of cGMP environments and regulatory expectations for controlled bioburden‑drug product manufacturing. Aseptic capability is a plus. Proven track record of leading multi‑functional teams and influencing technical decisions in complex, global organizations. Ability to support early‑phase design, detail design, start‑up processes, and Commissioning & Qualification (C&Q) of controlled bioburden (and aseptic) equipment. Experience with inherently safe containment design for components with low exposure level. Drive the adoption of digital and data‑enabled solutions for DP manufacturing, including real‑time monitoring, advanced process control, advanced analytics, model and simulation, and smart manufacturing use cases where they improve reliability and performance. Strong customer management and communication skills, with the ability to influence across sites, functions, and external partners. Strategic attitude combined with hands‑on technical capability. Intellectual curiosity to challenge the status quo, influence without authority, and cultivate an inclusive and collaborative culture. Proficiency in written and spoken English. Willingness to travel up to 25% domestically and internationally.

Preferred

Additional languages (Dutch, Spanish, Italian) are an advantage.

Required Skills Agile Decision Making, Coaching, Consulting, Corrective and Preventive Action (CAPA), Crisis Management, Cross‑Functional Collaboration, Disruptive Innovations, Emerging Technologies, Industrial Hygiene, Lean Supply Chain Management, Process Control, Process Engineering, Product Costing, Program Management, Project Schedule, Science, Technology, Engineering, and Math (STEM) Application, Tactical Planning, Technical Credibility, Technical Research. Pay Range

Primary posting location: €96,000.00 - €165,025.00 Italy: €70,700 - 122,015 EUR

Benefits In addition to base pay, we offer the following benefits: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well‑being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees — and in some location’s eligible dependents — can participate in several insurance plans. This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change. #J-18808-Ljbffr