Genomic and Environmental Mining of Novel Oxygen-Resistant [FeFe]-Hydrogenases and Engineering of Tailored Variants

ppOrganisation/Company Università di Torino Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 13 Oct 2026 - 13:00 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No /ph3Offer Description /h3pThe project builds on our research on CbA5H, the (FeFe)-hydrogenase from Clostridium beijerinckii isolated and characterized in our laboratory. Unlike most (FeFe)-hydrogenases, CbA5H shows intrinsic, reversible resistance to oxygen and other oxidants, overcoming a major limitation to their use in bioelectrochemical and catalytic systems despite high turnover rates and low overpotential. Comparative sequence analysis and the exploration of marine and extreme environments will identify enzymes carrying amino acid signatures associated with oxygen resistance. New genomic and metagenomic datasets will broaden sequence diversity and will guide the engineering of chimeric and site-directed variants of oxygen-sensitive hydrogenases. Recombinant production and testing of natural and engineered enzymes will expand the portfolio of robust catalysts for sustainable H₂ technologies, highlighting biodiversity as a resource for the energy transition. /ppMandatory requirement for admission to the selection: italian Laurea Magistrale, or Laurea a Ciclo Unico, or an equivalent degree from foreign Universities, obtained no more than 6 years prior to the application deadline (i.e obtained after 13/10/2020). The Call for Applications (published on the University Bulletin Board under ref. no. 4691 of 21/09/2026), containing the procedures to participate in the selection process and the specific requirements for each selection, is available at . /pulliItaly /li /ulpbEligibility of fellows: country/ies of residence: /b /pulliAll /li /ulpbEligibility of fellows: nationality/ies: /b /p /p #J-18808-Ljbffr